The Adipocyte, Fatty Acid Trapping, and Atherogenesis
نویسندگان
چکیده
منابع مشابه
The adipocyte, fatty acid trapping, and atherogenesis.
Much effort has been spent to identify the factors that contribute to coronary artery disease. Not surprisingly, adipose tissue has gained little attention to date in this search because no immediate and critical links between adipocyte metabolism and atherogenesis may be evident to most people. But coronary artery disease is a public health problem only in societies with high fatty acid intake...
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Mice null for adipocyte fatty acid binding protein ( A FABP) compensate by increasing expression of keratinocyte fatty acid binding protein (KFABP) (Hotamisligil et al. S c i e n c e 274:1377–1379, 1996). In the present s t u d y, AFABP knockout (KO) and wild-type (WT) mice became equally obese on a high-fat diet, as judged by fat pad weights, adipocyte size, and body composition analysis. High...
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23 The heart and blood vessels are surrounded by epicardial and perivascular adipose tissues 24 respectively, which play important roles in maintaining cardiovascular homeostasis by secreting 25 a number of biologically active molecules, termed “adipokines”. Many of these adipokines 26 function as an important component of the ‘adipo-cardiovascular axis’ mediating the cross-talk 27 between adip...
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It has been considered that a great deal of factors are concerned with pathogenesis. Aging is intimately involved with atherogenesis. There are many theories of aging mechanism, one of which is free radical theory. Auto-oxidation of fatty acid proceeds by a free-radical mechanism with formation of peroxides. X-ray irradiation, that is known to shorten lifespan, accelerates the peroxidation. Toc...
متن کاملKinetics of fatty acid interactions with fatty acid binding proteins from adipocyte, heart, and intestine.
Rate constants for the interaction of fatty acids (FA) with fatty acid binding proteins (FABP) from adipocyte (A-FABP), heart (H-FABP), and intestine (I-FABP) were determined by using stopped-flow fluorometry and ADIFAB, the fluorescent probe of free fatty acids (FFA), or a new FFA probe, ADIFAB2, constructed by derivatizing with acrylodan the Leu72 --> Ala mutant of I-FABP. ADIFAB2, because it...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 1998
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.18.2.147